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Citrobacter is a genus of Gram-negative, aerobic, rod-shapedcite-ref-0-2-0[2] coliform bacteria of the Enterobacteriaceae family.

Citrobacter spp. cause opportunistic infections (including urinary tract infections, gastroenteritis, and bacteremia).cite-ref-0-2-1[2]

• Microbiology

• Microbial biochemistry

• Environmental microbiology

• Clinical significance

• Antimicrobial resistance

• References

• External links

The species C. amalonaticus, C. koseri, and C. freundii can use citrate as a sole carbon source. Citrobacter species are differentiated by their ability to convert tryptophan to indole (C. koseri is the only citrobacter to be commonly indole-positive), ferment lactose (C. koseri is a lactose fermentor), and use malonate.cite-ref-seattle-va-3-0[3]

Citrobacter shows the ability to accumulate uranium by building phosphate complexes.cite-ref-4[4]

These bacteria can be found almost everywhere in soil, water, wastewater, etc. They can also be found in the human intestine.cite-ref-drelichman1985-5-0[5]cite-ref-badger1999-6-0[6]

Citrobacter are considered opportunistic nosocomial pathogens, typically associated with urinary tract infections and infant meningitis and sepsis.cite-ref-jabeen2023-7-0[7]

Citrobacter freundii strains have inducible ampC genes encoding resistance to ampicillin and first-generation cephalosporins.cite-ref-8[8] In addition, isolates of Citrobacter may be resistant to many other antibiotics as a result of plasmid-encoded resistance genes.cite-ref-jabeen2023-7-1[7]

cite-note-citrobacter-11. citerefparteParte, A.C. "Citrobacter". LPSN. Retrieved 18 October 2018.

cite-note-0-22. ↑ "Dictionnaire médical de l'Académie de Médecine" [Medical Dictionary of the Academy of Medicine]. www.academie-medecine.fr (in French). Retrieved 2024-01-13.

cite-note-seattle-va-33. ↑ citereflipskyhook-iiismithplorde1980Lipsky, Benjamin A.; Hook III, Edward W.; Smith, Arlene A.; Plorde, James J. (1980). "Citrobacter Infections in Humans: Experience at the Seattle Veterans Administration Medical Center and a Review of the Literature". Clinical Infectious Diseases. 2 (5): 746–760. doi:10.1093/clinids/2.5.746. ISSN 1058-4838. PMID 6763304.

cite-note-44. ↑ citerefmacaskieempsoncheethamgrey1992Macaskie, Lynne E.; Empson, Ruth M.; Cheetham, Anthony K.; Grey, Clare P.; Skarnulis, A. Jerome (1992). "Uranium bioaccumulation by a Citrobacter sp. as a result of enzymically mediated growth of polycrystalline HUO2PO4". Science. 257 (5071): 782–784. Bibcode:1992Sci...257..782M. doi:10.1126/science.1496397. ISSN 0036-8075. PMID 1496397.

cite-note-drelichman1985-55. ↑ citerefdrelichmanband1985Drelichman, Vilma; Band, Jeffrey D. (1985). "Bacteremias due to Citrobacter diversus and Citrobacter freundii. Incidence, risk factors, and clinical outcome". Archives of Internal Medicine. 145 (10): 1808–1810. doi:10.1001/archinte.145.10.1808. PMID 3899035.

cite-note-badger1999-66. ↑ citerefbadgerm-f-stinskim1999Badger, Julie D.; M.F. Stins, Monique F.; Kim, Kwang Sik (1999). "Citrobacter freundii Invades and Replicates in Human Brain Microvascular Endothelial Cells". Infection and Immunity. 67 (8): 4208–4215. PMC 96726. PMID 10417193.

cite-note-jabeen2023-77. ↑ citerefjabeenislamhassantasnim2023Jabeen, Ishrat; Islam, Sohidul; Hassan, A. K. M. Imrul; Tasnim, Zerin; Shuvo, Sabbir R. (2023). "A brief insight into Citrobacter species–a growing threat to public health". Frontiers in Antibiotics. 2. doi:10.3389/frabi.2023.1276982/full. ISSN 2813-2467.

cite-note-88. ↑ citerefmeinitasciniceisozio2019Meini, Simone; Tascini, Carlo; Cei, Marco; Sozio, Emanuela; Rossolini, Gian Maria (2019). "AmpC β-lactamase-producing Enterobacterales: what a clinician should know". Infection. 47 (3): 363–375. doi:10.1007/s15010-019-01291-9. ISSN 1439-0973.

• Citrobacter at DSMZ - German Collection of Microorganisms and Cell Cultures

• Canada Public Health Data Sheet